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resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR/HER2 advanced breast cancer (ABC).review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR/HER2 ABC.addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR

Keywords： endocrine-resistant     HR<sup>+sup>/HER2<sup>-sup> advanced breast cancer     randomized clinical trials    

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frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas and breast

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: the analysis of the splicing variants of an oncogene Focal Adhesion Kinase (FAK) in The CancerGenome Atlas datasets that contain 9193 patients of 33 cancer subtypes, we found that Box 6/Box 7-containing%) of 40 pancreatic solid pseudopapillary neoplasms, and 2 (2.9%) of 69 PDACsin 23 non-NEC breast cancers.>6/7sup>-positive pancreatic tumors and breast tumors, which promoted the formation of FAK

Keywords： FAK<sup>6/7sup>     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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RNA m<sup>6sup>A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 481-489 doi: 10.1007/s11684-018-0654-8

Abstract:

N<sup>6sup>-methyladenosine (m<sup>6sup>A) is the most common post-transcriptional RNAsup>A modification could be installed by m<sup>6sup>A “writers” composed of core catalyticThe function of m<sup>6sup>A is executed by m<sup>6sup>A “readers” that bind to m<sup>6sup>A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1).However, the mechanism and the regulatory network of m<sup>6sup>A are still largely unknown.

Keywords： RNA modification     m<sup>6sup>A     immunity     cancer     epigenetics    

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Study on Algorithm A<sup>*sup> Based on Dynamic Representation of Binary Tree for Environment and Robotic

Tang Ping,Yang Yimin

Strategic Study of CAE 2002, Volume 4, Issue 9,   Pages 50-53

Abstract: A new algorithm A<sup>*sup> , which plans the path of soccer robots in complicated environments is

Keywords： dynamic binary-tree     algorithm A<sup>*sup>     path planning    

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Clinical significance of CD34<sup>+sup>CD117<sup>dimsup>/CD34<sup>+sup>CD117<sup>brisup> myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy with a high relapse rate in China. Two leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21) AML, and CD34 CD117 cell proportion was determined as an independent factor for this disease outcome. Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;21) AML clinical prognosis. In this study, 85 patients with t(8;21) AML were enrolled. The mRNA expression levels of CD34 CD117 -associated genes ( , , and ) and CD34 CD117 -associated genes ( , , and ) were measured using quantitative reverse transcription PCR. Associations between gene expression and clinical outcomes were determined using Cox regression models. Results showed that patients with high , , or expression had significantly inferior overall survival (OS), whereas those with high or expression showed relatively favorable prognosis. Univariate analysis revealed that CD19, CD34 CD117 proportion, mutation, minimal residual disease (MRD), and expression levels of , , , and were associated with OS. Multivariate analysis indicated that mutation, MRD and and expression levels were independent prognostic variables for OS. Identifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may provide new clinically prognostic markers for t(8;21) AML.

Keywords： t(8     21)(q22     q22) AML     CD34<sup>+sup>CD117<sup>dimsup>/ CD34<sup>+sup>CD117<sup>brisup> cell population    

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K<sup>+sup> and Na<sup>+sup> fluxes in roots of two Chinese Iris populations

Pinfang LI,Biao ZHANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 144-149 doi: 10.15302/J-FASE-2014016

Abstract: Maintenance of ion homeostasis, particularly the regulation of K and Na uptake, is important for all plants to adapt to salinity. Observations on ionic response to salinity and net fluxes of K , Na in the root exhibited by plants during salt stress have highlighted the need for further investigation. The objectives of this study were to compare salt adaptation of two Chinese Iris ( Pall. var. (Fisch.) Koidz.) populations, and to improve understanding of adaptation to salinity exhibited by plants. Plants used in this study were grown from seeds collected in the Xinjiang Uygur Autonomous Region (Xj) and Beijing Municipality (Bj), China. Hydroponically-grown seedlings of the two populations were supplied with nutrient solutions containing 0.1 (control) and 140 mmol·L NaCl. After 12 days, plants were harvested for determination of relative growth rate and K , Na concentrations. Net fluxes of K , Na from the apex and along the root axis to 10.8 mm were measured using non-invasive micro-test technique. With 140 mmol·L NaCl treatment, shoots for population Xj had larger relative growth rate and higher K concentration than shoots for population Bj. However, the Na concentrations in both shoots and roots were lower for Xj than those for Bj. There was a lower net efflux of K found in population Xj than by Bj in the mature zone (approximately 2.4-10.8 mm from root tip). However, no difference in the efflux of Na between the populations was obtained. Population Xj of continued to grow normally under NaCl stress, and maintained a higher K /Na ratio in the shoots. These traits, which were associated with lower K leakage, help population Xj adapt to saline environments.

Keywords： Koidz     population     K<sup>+sup> and Na<sup>+sup>     ion flux     non-invasive micro-test technique    

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Selective recovery of Cu

Haiping LUO,Bangyu QIN,Guangli LIU,Renduo ZHANG,Yabo TANG,Yanping HOU

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 3,   Pages 522-527 doi: 10.1007/s11783-014-0633-5

Abstract: As the bioelectrochemical system, the microbial fuel cell (MFC) and the microbial electrolysis cell (MEC) were developed to selectively recover Cu and Ni ions from wastewater. The wastewater was treated in the cathode chambers of the system, in which Cu and Ni ions were removed by using the MFC and the MEC, respectively. At an initial Cu concentration of 500 mg·L , removal efficiencies of Cu increased from 97.0%±1.8% to 99.0%±0.3% with the initial Ni concentrations from 250 to 1000 mg·L , and maximum power densities increased from 3.1±0.5 to 5.4±0.6 W·m . The Ni removal mass in the MEC increased from 6.8±0.2 to 20.5±1.5 mg with the increase of Ni concentrations. At an initial Ni concentration of 500 mg·L , Cu removal efficiencies decreased from 99.1%±0.3% to 74.2%±3.8% with the initial Cu concentrations from 250 to 1000 mg·L , and maximum power densities increased from 3.0±0.1 to 6.3±1.2 W·m . Subsequently, the Ni removal efficiencies decreased from 96.9%±3.1% to 73.3%±5.4%. The results clearly demonstrated the feasibility of selective recovery of Cu and Ni from the wastewater using the bioelectrochemical system.

Keywords： bioelectrochemical system     Cu<sup>2+sup>     Ni<sup>2+sup>     selective recovery    

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Removal of ammonium and nitrate through Anammox and FeS-driven autotrophic denitrification

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 6, doi: 10.1007/s11783-023-1674-4

Abstract:

● Simultaneous NH4<sup>+sup>/NO3<sup>–sup

Keywords： Anammox     Denitrification     FeS     NH4<sup>+sup>/NO3<sup>−sup>     Sulfammox    

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Effect of noble metal nanoparticle size on C–N bond cleavage performance in hydrodenitrogenation: a study of active sites

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1986-2000 doi: 10.1007/s11705-023-2337-5

Abstract: obtained by modulating the reduction temperature, and the catalytic activity was evaluated using 1,2,3,4Results showed a 13 times higher reaction rate for sp<sup>3sup>-hybridized C–N bond cleavage than sp<sup>2sup>-hybridized C–N bond cleavage, while the reaction rate tended to increase first and then

Keywords： sp<sup>3sup>/sp<sup>2sup>-hybridized C–N bond     noble metal nanoparticle     catalytic active site     turnover    

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An electrochemical process that uses an Fe

Chaojie Jiang, Lifen Liu, John C. Crittenden

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 4, doi: 10.1007/s11783-016-0860-z

Abstract: A bio-electrochemical fuel cell reactor with cathodic Fe /TiO generates electricity. It destroys recalcitrant pollutants in cathode chamber without photocatalysis. Fe /TiO generates reactive oxygenated species in the dark or under photocatalysis. Cathodic produced ROS (hydroxy radical/superoxide radical) can degrade tetracycline or dyes. Electricity generation is enhanced by semiconductor catalyzed cathodic degradation of pollutants. In this study, a new water treatment system that couples (photo-) electrochemical catalysis (PEC or EC) in a microbial fuel cell (MFC) was configured using a stainless-steel (SS) cathode coated with Fe /TiO . We examined the destruction of methylene blue (MB) and tetracycline. Fe /TiO was prepared using a chemical reduction-deposition method and coated onto an SS wire mesh (500 mesh) using a sol technique. The anode generates electricity using microbes (bio-anode). Connected via wire and ohmic resistance, the system requires a short reaction time and operates at a low cost by effectively removing 94% MB (initial concentration 20 mg·L ) and 83% TOC/TOC under visible light illumination (50 W; 1.99 mW·cm for 120 min, MFC-PEC). The removal was similar even without light irradiation (MFC-EC). The of the MFC-PEC system was approximately 0.675 kWh·m ·order , whereas that of the MFC-EC system was zero. The system was able to remove 70% COD in tetracycline solution (initial tetracycline concentration 100 mg·L ) after 120 min of visible light illumination; without light, the removal was 15% lower. The destruction of MB and tetracycline in both traditional photocatalysis and photoelectrocatalysis systems was notably low. The electron spin-resonance spectroscopy (ESR) study demonstrated that ·OH was formed under visible light, and ·O was formed without light. The bio-electricity-activated O and ROS (reactive oxidizing species) generation by Fe /TiO effectively degraded the pollutants. This cathodic degradation improved the electricity generation by accepting and consuming more electrons from the bio-anode.

Keywords： Bio-anode     Photocatalytic cathode     Fe<sup>0sup>/TiO2     ESR     Dye and antibiotics     Advanced oxidation    

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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: Neuropilin and tolloid-like 2 (NETO2) is closely related to tumorigenesis.However, the functional significance of NETO2 in melanoma progression remains unclear.invasion by downregulating the levels of calcium ions (Ca<sup>2+sup>) and the expression of key genesBy contrast, NETO2 overexpression had the opposite effects.indicating that targeting NETO2 may effectively improve melanoma treatment.

Keywords： melanoma     neuropilin and tolloid-like 2     Ca<sup>2+sup>/CaMKII signaling pathway    

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Advances of 12<sup>thsup> CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 461-463 doi: 10.1007/s11705-020-2026-6

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Advanced nitrogen and phosphorus removal in A

Jianhua WANG, Yongzhen PENG, Yongzhi CHEN

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 3,   Pages 474-480 doi: 10.1007/s11783-011-0360-0

Abstract: zone in A O process was also investigated, and the results demonstrated that the optimum value was 1∶6∶2.

Keywords： Anoxic zone and biologic aerated filter (A<sup>2sup>O-BAF) system     domestic wastewater with low carbon-to-nitrogenratio     advanced nitrogen and phosphorus removal     denitrifying phosphorus removal    

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Calculation of H2<sup>+sup> Structural Parameters based on Hydrogen Atomic Protonized Model

Chen Jing

Strategic Study of CAE 2004, Volume 6, Issue 11,   Pages 29-32

Abstract:

The hydrogen atomic protonized model was introduced in present paper for calculation of H2<sup>+sup> structural parameters.above model for bond-length, bond-energy and force constant of hydrogen molecule ion were Re=2aWhen atomic-unit used,they are respectively Re= 2au., De=0.109735au. and k=0.109735au

Keywords： hydrogen molecule ion     bond-length     bond-energy     force constant    

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Symbiotic performance, shoot biomass and water-use efficiency of three groundnut (

Sofiya K. MUHABA, Felix D. DAKORA

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 4,   Pages 455-466 doi: 10.15302/J-FASE-2020354

Abstract:

Phosphorus is a key nutrient element involved in energy transfer for cellular metabolism, respiration and photosynthesis and its supply at low levels can affect legume nodulation, N fixation, and C assimilation. A two-year field study was conducted in Ethiopia in 2012 and 2013 to evaluate the effects of P supply on growth, symbiotic N nutrition, grain yield and water-use efficiency of three groundnut genotypes. Supplying P to the genotypes significantly increased their shoot biomass, symbiotic performance, grain yield, and C accumulation. There was, however, no effect on shoot δ C values in either year. Compared to the zero-P control, supplying 40 kg·ha P markedly increased shoot biomass by 77% and 66% in 2012 and 2013, respectively. In both years, groundnut grain yields were much higher at 20 and 30 kg·ha P. Phosphorus supply markedly reduced shoot δ N values and increased the %Ndfa and amount of N-fixed, indicating the direct involvement of P in promoting N fixation in nodulated groundnut. The three genotypes differed significantly in δ N, %Ndfa, N-fixed, grain yield, C concentration, and δ C. The phosphorus × genotype interaction was also significant for shoot DM, N content, N-fixed and soil N uptake.

Keywords： shoot yield     N-fixed     %Ndfa     δ<sup>15sup>N     δ<sup>13sup>C     water-use efficiency    

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Title Author Date Type Operation

resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor receptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article

frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas and breast

Journal Article

RNA m<sup>6sup>A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Journal Article

Study on Algorithm A<sup>*sup> Based on Dynamic Representation of Binary Tree for Environment and Robotic

Tang Ping,Yang Yimin

Journal Article

Clinical significance of CD34<sup>+sup>CD117<sup>dimsup>/CD34<sup>+sup>CD117<sup>brisup> myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

K<sup>+sup> and Na<sup>+sup> fluxes in roots of two Chinese Iris populations

Pinfang LI,Biao ZHANG

Journal Article

Selective recovery of Cu

Haiping LUO,Bangyu QIN,Guangli LIU,Renduo ZHANG,Yabo TANG,Yanping HOU

Journal Article

Removal of ammonium and nitrate through Anammox and FeS-driven autotrophic denitrification

Journal Article

Effect of noble metal nanoparticle size on C–N bond cleavage performance in hydrodenitrogenation: a study of active sites

Journal Article

An electrochemical process that uses an Fe

Chaojie Jiang, Lifen Liu, John C. Crittenden

Journal Article

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Journal Article

Advances of 12<sup>thsup> CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

Journal Article

Advanced nitrogen and phosphorus removal in A

Jianhua WANG, Yongzhen PENG, Yongzhi CHEN

Journal Article

Calculation of H2<sup>+sup> Structural Parameters based on Hydrogen Atomic Protonized Model

Chen Jing

Journal Article

Symbiotic performance, shoot biomass and water-use efficiency of three groundnut (

Sofiya K. MUHABA, Felix D. DAKORA

Journal Article